Organisation

Représentant: Françoise PEYRIN

Team #1 “Modeling and Imaging of Vessels, Thorax and Brain - MOTIVATE” (Project Leader: P. Clarysse) develops new-dedicated acquisition techniques and model based quantification methods to better assess 3D organ anatomy, tissues and function at various scales from human examinations and animal experiments. Cardio-vascular and pulmonary diseases, responsible for more than 40% death in the developed countries, constitute the main targets of our research. More specifically, we notably aim at 1) confronting simulated flows from extracted 3D shapes to experimental flow MRI measurements in vessels and vessel networks 2) confronting in-vivo human heart shape and fibre architecture to heart dynamics to better understand the cardiac remodelling process through aging 3) characterizing ventilator-induced lung injuries from PET imaging and at bedside Electrical Impedance Tomography. The team is therefore closely involved in the management of clinical and pre-clinical settings at Hospice Civils de Lyon. Pr P. Douek is chairman of a consortium of 10 departments of Radiology and Nuclear Medicine at HCL. This multidisciplinary team is composed of 12 permanent people; half of them are MDs (4 PUPH, 2MCUPH), the other half being from engineering background (1 DR Inserm, 2 DR CNRS, 1 PU, 1 MCU, 1 Ing.). Since 2007, it has produced more than 90 papers in peer reviewed journals, 12 book chapters, 1 book, 80 papers in international conferences and 9 invited conferences. The team is involved in two ANR projects and the THROMBUS STREP European FP7 project related to the VPH-NoE (Pilot: G. Courbebaisse).

Team #2 «Images and Models » (Project Leader: Rémy Prost) develops methods for Patient Specific Model construction based on Virtual Humans approach and an associated Virtual Imaging Platform. Based on these enriched models effective Computer-Aided Diagnosis Systems are designed. The following topics are part of the research: parametric and geometric model design; Computer-Aided Diagnosis (CAD) based on multi-modality imaging; feature and parameters extraction for model enhancement; data management and massive computing; Virtual Imaging Platform (VIP); collaborative research projects (Virtual Human, quantitative MRI for nano particles, interactive registration and segmentation). Ten of the twelve permanent researchers of Team 2 (3 PU-INSA, 3 MdC-INSA, 3 CR CNRS, 1 IR CNRS) are involved in the Labex proposal. Since 2007, these ten researchers produced 45 papers in peer reviewed journals, 4 book chapters, 97 papers in international conferences. The team is involved in three ANR projects and several FP7 projects related to the Virtual Physiological Human (NoE VPH, 2008-12), Hadron therapy (ENVISION 2010-13), SHIWA.

Team #3 «Ultrasound Imaging» (Project Leader: Philippe Delachartre) develops signal and image processing methods that can characterize biological media imaged with ultrasound imaging system. We work on ultrasound images or image sequences in order to go back to the medium properties owing to 3 complementary axes: the control of imaging system in both transmission and reception, the estimation of motion field of the medium (soft tissue or blood) and the parametric or multimodality imaging (US/MRI and US/optic). The methods we develop are based on physical models to estimate the parameters of elasticity, movement or non-linearity of biological media. The image formation is adapted to the methods based on the acquisition of radio frequency signals (RF). Whenever possible, the methods are developed to operate in real time i.e. the rate of acquisition of images by the system and are extended to 3D data and processing

Team #4 «Tomographic imaging and Therapy using Radiation» (Project Leader: Françoise Peyrin) develops research activities in tomographic imaging methods and image guided radiotherapy. The team has a long experience in X-ray CT methods from a theoretical and practical point of view. The team combines research on inverse problems, tomographic reconstruction, 3D X-Ray CT imaging, 3D/4D image registration as well as simulations for therapy ion beams. Two major areas of application are bone imaging and 3D radiation therapy for cancer treatment. The team has close collaborations with two major technical platforms in the Rhône-Alpes: the European Synchrotron Radiation Facility (ESRF) in Grenoble, and the technical support of the Department of Radiotherapy Centre Léon Bérard (CLB). The team is composed of 10 permanent researchers (1 INSERM, 3 CNRS, 5 MdC INSA, 1 MD). Since 2007, it has produced more than 100 papers in peer reviewed journals, 5 book chapters, 90 papers in international conferences and 19 invited conferences. The team is involved in four ANR projects and several FP7 projects related to Hadrontherapy. It has already successfully been working with different partners of this project (in particular IPNL, Gin Grenoble, CEA-LETI).

Team #5 «MRI and Optics : Methods and Systems » (Project Leader: Olivier Beuf). The objectives are to address Optics and NMR modalities to be operated in synergy and provide in vivo relevant metabolic and functional information in addition to anatomy. We develop methods (MR signal acquisition/processing) and instruments (radio frequency and optoelectronic devices design) for liver imaging, gastro-intestinal wall exploration, musculosqueletal characterization as well as brain functional imaging. Optical instrumentation is developed to design and build multimodal systems. This team is composed of 3 CNRS researchers and engineer, 6 teacher-researchers teaching in the biomedical department of Lyon 1 (EPUL). It is a regular user of the “CERMEP” technology platform, the team works intimately with the Hospices Civil de Lyon and maintained international collaborations with UC San Francisco and University of Singapore. Since 2007, members of the team published 47 papers in peer reviewed journals, 3 patents, 1 book chapters, 98 papers in international conferences. The team is currently involved in 7 funded project including ANR projects. It has been working successfully with several partners presented in this document (e.g. CRNL, Laboratory Hubert Curien, CEA-LETI).